Synthesis and Evaluation of Anticancer Activity of Hyaluronic Acid/Vanillin Conjugates

Natural phenolic compounds are known not only for their multiple bioactivities but also low bioavailability and rapid metabolism in the systemic circulation. It is well-known that grafting these to bio-based polymers such as hyaluronic acid (HA), has advantage increase stability water solubility. HA CD44 receptors overexpressed on cancer cells. This makes from an interesting vector antitumor drug delivery systems. The work reported herein describes synthesis structural characterization of HA/vanillin conjugates well size shape aqueous microassemblies using dynamic light scattering electron microscopy. Finally, investigation bioactivity demonstrates vanillin improves significantly its cytotoxicity against MDA-MB231 cells both dose time-dependent manner, reduces migration ability number volume breast spheres.